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The New Phentermine Cocktail: "Phen-Pro” Since 1996 the FDA has approved three long-term treatments for weight control: dexfenfluramine (Redux and Pondimin), sibutramine (Meridia) and orlistat (Xenical). Dexfenfluramine, which took the market by storm when mixed with Phentermine, was withdrawn within 18 months of approval after it was shown to be associated with severe disabilities from heart valve disorders